Development and validation of a questionnaire-based myopia proxy in adults: the LifeLines Cohort Study

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Abstract

Aims To build a questionnaire-based myopia proxy and to validate the proxy by confirming its association with educational attainment and a Polygenic Risk Score (PRS) for myopia. Methods Data were collected between 2014 and 2017 from 88 646 Dutch adults from the LifeLines Cohort. First, we performed principal component analysis (PCA) to responses of five refraction-status questions. Second, we measured the refractive state in a subset of LifeLines participants (n=326) and performed logistic regression using myopia (mean spherical equivalent

Original languageEnglish
Number of pages8
JournalBRITISH JOURNAL OF OPHTHALMOLOGY
DOIs
Publication statusE-pub ahead of print - 10-Mar-2022

Keywords

  • optics and refraction
  • public health
  • epidemiology
  • REFRACTIVE ERROR
  • PREVALENCE
  • POPULATION
  • VALIDITY
  • EUROPE
  • AGE

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