Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors

Masahiro Morimoto; Henk P. Bijl; Arjen van der Schaaf; Cheng-Jian Xu; Roel J. H. M. Steenbakkers; Olga Chouvalova; Yasuo Yoshioka; Teruki Teshima; Johannes A. Langendijk

doi:10.21873/anticanres.13894

Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors

Masahiro Morimoto^*, Henk P. Bijl, Arjen van der Schaaf, Cheng-Jian Xu, Roel J. H. M. Steenbakkers, Olga Chouvalova, Yasuo Yoshioka, Teruki Teshima, Johannes A. Langendijk

^*Corresponding author for this work

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

44 Downloads (Pure)

Abstract

BACKGROUND/AIM: The aim of this study was to develop a normal tissue complication probability (NTCP) model for trismus in head and neck cancer (HNC) patients treated with radiotherapy (RT).

PATIENTS AND METHODS: Prospective measurements of maximum inter-incisal opening (MIO) were performed at baseline and 6 months after definitive RT in 132 HNC patients. The primary endpoint of this study was defined when a patient fulfilled both of the following criteria: 1) MIO at 6 months after RT ≤35 mm and 2) MIO at 6 months after RT ≤80% of baseline MIO. Eleven clinical factors and a wide range of dosimetric factors (mean dose, maximum dose, V5, V10, V20, and V40) in twelve organs at risk (OARs) were chosen as candidate prognostic variables.

RESULTS: Thirty out of 132 patients (23%) developed the primary endpoint. Multivariate logistic regression analysis revealed that the mean dose to the contralateral mandible joint (p=0.001) and baseline MIO (p=0.027) were independent prognostic factors.

CONCLUSION: A multivariable NTCP model for trismus in HNC patients treated with RT was established including the mean dose to contralateral mandible joint and baseline MIO.

Original language	English
Pages (from-to)	6787-6798
Number of pages	12
Journal	Anticancer Research
Volume	39
Issue number	12
DOIs	https://doi.org/10.21873/anticanres.13894
Publication status	Published - Dec-2019

Keywords

Head and neck cancer
radiotherapy
trismus
normal tissue complication probability model
prediction
RADIATION-INDUCED TRISMUS
QUALITY-OF-LIFE
NASOPHARYNGEAL CARCINOMA
EXERCISE THERAPY
PENTOXIFYLLINE
PREVENTION
ONCOLOGY
FIBROSIS
IMPACT

Access to Document

10.21873/anticanres.13894

Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy_ The Role of Dosimetric and Clinical FactorsFinal publisher's version, 539 KBLicence: Taverne

Handle.net

Persistent link

Cite this

Morimoto, M., Bijl, H. P., van der Schaaf, A., Xu, C.-J., Steenbakkers, R. J. H. M., Chouvalova, O., Yoshioka, Y., Teshima, T., & Langendijk, J. A. (2019). Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors. Anticancer Research, 39(12), 6787-6798. https://doi.org/10.21873/anticanres.13894

@article{b0b362e2df0e420dab534afcee050768,

title = "Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors",

abstract = "BACKGROUND/AIM: The aim of this study was to develop a normal tissue complication probability (NTCP) model for trismus in head and neck cancer (HNC) patients treated with radiotherapy (RT).PATIENTS AND METHODS: Prospective measurements of maximum inter-incisal opening (MIO) were performed at baseline and 6 months after definitive RT in 132 HNC patients. The primary endpoint of this study was defined when a patient fulfilled both of the following criteria: 1) MIO at 6 months after RT ≤35 mm and 2) MIO at 6 months after RT ≤80% of baseline MIO. Eleven clinical factors and a wide range of dosimetric factors (mean dose, maximum dose, V5, V10, V20, and V40) in twelve organs at risk (OARs) were chosen as candidate prognostic variables.RESULTS: Thirty out of 132 patients (23%) developed the primary endpoint. Multivariate logistic regression analysis revealed that the mean dose to the contralateral mandible joint (p=0.001) and baseline MIO (p=0.027) were independent prognostic factors.CONCLUSION: A multivariable NTCP model for trismus in HNC patients treated with RT was established including the mean dose to contralateral mandible joint and baseline MIO.",

keywords = "Head and neck cancer, radiotherapy, trismus, normal tissue complication probability model, prediction, RADIATION-INDUCED TRISMUS, QUALITY-OF-LIFE, NASOPHARYNGEAL CARCINOMA, EXERCISE THERAPY, PENTOXIFYLLINE, PREVENTION, ONCOLOGY, FIBROSIS, IMPACT",

author = "Masahiro Morimoto and Bijl, {Henk P.} and {van der Schaaf}, Arjen and Cheng-Jian Xu and Steenbakkers, {Roel J. H. M.} and Olga Chouvalova and Yasuo Yoshioka and Teruki Teshima and Langendijk, {Johannes A.}",

year = "2019",

month = dec,

doi = "10.21873/anticanres.13894",

language = "English",

volume = "39",

pages = "6787--6798",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "INT INST ANTICANCER RESEARCH",

number = "12",

}

Morimoto, M, Bijl, HP , van der Schaaf, A, Xu, C-J, Steenbakkers, RJHM , Chouvalova, O, Yoshioka, Y, Teshima, T & Langendijk, JA 2019, 'Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors', Anticancer Research, vol. 39, no. 12, pp. 6787-6798. https://doi.org/10.21873/anticanres.13894

Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors. / Morimoto, Masahiro; Bijl, Henk P.; van der Schaaf, Arjen et al.
In: Anticancer Research, Vol. 39, No. 12, 12.2019, p. 6787-6798.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy

T2 - The Role of Dosimetric and Clinical Factors

AU - Morimoto, Masahiro

AU - Bijl, Henk P.

AU - van der Schaaf, Arjen

AU - Xu, Cheng-Jian

AU - Steenbakkers, Roel J. H. M.

AU - Chouvalova, Olga

AU - Yoshioka, Yasuo

AU - Teshima, Teruki

AU - Langendijk, Johannes A.

PY - 2019/12

Y1 - 2019/12

N2 - BACKGROUND/AIM: The aim of this study was to develop a normal tissue complication probability (NTCP) model for trismus in head and neck cancer (HNC) patients treated with radiotherapy (RT).PATIENTS AND METHODS: Prospective measurements of maximum inter-incisal opening (MIO) were performed at baseline and 6 months after definitive RT in 132 HNC patients. The primary endpoint of this study was defined when a patient fulfilled both of the following criteria: 1) MIO at 6 months after RT ≤35 mm and 2) MIO at 6 months after RT ≤80% of baseline MIO. Eleven clinical factors and a wide range of dosimetric factors (mean dose, maximum dose, V5, V10, V20, and V40) in twelve organs at risk (OARs) were chosen as candidate prognostic variables.RESULTS: Thirty out of 132 patients (23%) developed the primary endpoint. Multivariate logistic regression analysis revealed that the mean dose to the contralateral mandible joint (p=0.001) and baseline MIO (p=0.027) were independent prognostic factors.CONCLUSION: A multivariable NTCP model for trismus in HNC patients treated with RT was established including the mean dose to contralateral mandible joint and baseline MIO.

AB - BACKGROUND/AIM: The aim of this study was to develop a normal tissue complication probability (NTCP) model for trismus in head and neck cancer (HNC) patients treated with radiotherapy (RT).PATIENTS AND METHODS: Prospective measurements of maximum inter-incisal opening (MIO) were performed at baseline and 6 months after definitive RT in 132 HNC patients. The primary endpoint of this study was defined when a patient fulfilled both of the following criteria: 1) MIO at 6 months after RT ≤35 mm and 2) MIO at 6 months after RT ≤80% of baseline MIO. Eleven clinical factors and a wide range of dosimetric factors (mean dose, maximum dose, V5, V10, V20, and V40) in twelve organs at risk (OARs) were chosen as candidate prognostic variables.RESULTS: Thirty out of 132 patients (23%) developed the primary endpoint. Multivariate logistic regression analysis revealed that the mean dose to the contralateral mandible joint (p=0.001) and baseline MIO (p=0.027) were independent prognostic factors.CONCLUSION: A multivariable NTCP model for trismus in HNC patients treated with RT was established including the mean dose to contralateral mandible joint and baseline MIO.

KW - Head and neck cancer

KW - radiotherapy

KW - trismus

KW - normal tissue complication probability model

KW - prediction

KW - RADIATION-INDUCED TRISMUS

KW - QUALITY-OF-LIFE

KW - NASOPHARYNGEAL CARCINOMA

KW - EXERCISE THERAPY

KW - PENTOXIFYLLINE

KW - PREVENTION

KW - ONCOLOGY

KW - FIBROSIS

KW - IMPACT

U2 - 10.21873/anticanres.13894

DO - 10.21873/anticanres.13894

M3 - Article

C2 - 31810944

SN - 0250-7005

VL - 39

SP - 6787

EP - 6798

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

Development of Normal Tissue Complication Probability Model for Trismus in Head and Neck Cancer Patients Treated With Radiotherapy: The Role of Dosimetric and Clinical Factors

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this