Dextran-magnetite particles: contrast-enhanced MRI of blood-brain barrier disruption in a rat model

JW Bulte; MWA de Jonge; R Kamman; Kian G Go; Fred Zuiderveen; Bert Blaauw; John A. Oosterbaan; Tjwan Hauw The; Lou de Leij

doi:10.1002/mrm.1910230203

Dextran-magnetite particles: contrast-enhanced MRI of blood-brain barrier disruption in a rat model

JW Bulte, MWA de Jonge, R Kamman, Kian G Go, Fred Zuiderveen, Bert Blaauw, John A. Oosterbaan, Tjwan Hauw The, Lou de Leij

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Abstract

Dextran‐magnetite particles (DMP) were studied for their use as a MR contrast agent to visualize lesions with a blood‐brain barrier (bbb) disruption. A freezing injury to the rat cerebral cortex was used as a model of bbb disruption. The biodistribution of iv‐injected DMP was studied using atomic absorption spectrophotometry, electron microscopy, and MRI. One hour after injection, focal accumulation of the particles in capillary endothelial cells could be demonstrated in the freezing lesion. Despite the observation that the relaxivity of DMP in vivo appears to be less well pronounced than that in vitro, the MR imaging studies show that DMP can be used to visualize bbb disruption with adequate contrast.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910230203
Publication status	Published - Feb-1992

Keywords

SUPERPARAMAGNETIC IRON-OXIDE
FERRITE PARTICLES
AGENT
RELAXATION
LIVER

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Dextran‐magnetite particles
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title = "Dextran-magnetite particles: contrast-enhanced MRI of blood-brain barrier disruption in a rat model",

abstract = "Dextran‐magnetite particles (DMP) were studied for their use as a MR contrast agent to visualize lesions with a blood‐brain barrier (bbb) disruption. A freezing injury to the rat cerebral cortex was used as a model of bbb disruption. The biodistribution of iv‐injected DMP was studied using atomic absorption spectrophotometry, electron microscopy, and MRI. One hour after injection, focal accumulation of the particles in capillary endothelial cells could be demonstrated in the freezing lesion. Despite the observation that the relaxivity of DMP in vivo appears to be less well pronounced than that in vitro, the MR imaging studies show that DMP can be used to visualize bbb disruption with adequate contrast.",

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AU - Zuiderveen, Fred

AU - Blaauw, Bert

AU - Oosterbaan, John A.

AU - The, Tjwan Hauw

AU - de Leij, Lou

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AB - Dextran‐magnetite particles (DMP) were studied for their use as a MR contrast agent to visualize lesions with a blood‐brain barrier (bbb) disruption. A freezing injury to the rat cerebral cortex was used as a model of bbb disruption. The biodistribution of iv‐injected DMP was studied using atomic absorption spectrophotometry, electron microscopy, and MRI. One hour after injection, focal accumulation of the particles in capillary endothelial cells could be demonstrated in the freezing lesion. Despite the observation that the relaxivity of DMP in vivo appears to be less well pronounced than that in vitro, the MR imaging studies show that DMP can be used to visualize bbb disruption with adequate contrast.

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KW - AGENT

KW - RELAXATION

KW - LIVER

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Dextran-magnetite particles: contrast-enhanced MRI of blood-brain barrier disruption in a rat model

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Keywords

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