Diabetes mellitus and rhegmatogenous retinal detachment: Exploring the role of advanced glycation endproducts in systemic and local disease

Bernardina Teunisje Fokkens

    Research output: ThesisThesis fully internal (DIV)

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    Abstract

    Along with ageing of the population, the prevalence of many age related diseases is rising. The
    troublesome complications that accompany these diseases have a high impact on patients’ daily
    live. To reduce this impact, it is not only important to treat the diseases well, but also to detect the
    diseases in an early stage. Especially, diseases that affect the eye, since the cells of the eye have
    little or no regenerative capacity. Clinical parameters can help to identify patients at higher risk
    of diseases and complications, but they are not sensitive and specific enough. This emphasizes
    the need for new biomarkers that could be used (in addition to clinical parameters) to identify
    patients at high risk of specific diseases and complications.

    This thesis addresses the role of an emerging group of biomarkers, called advanced glycation
    endproducts (AGEs), in diabetes mellitus (DM) and in rhegmatogenous retinal detachment (RRD).
    AGEs are formed during chemical processes in which free amino groups of proteins, lipids, and
    nucleic acids become glycated. Elevated levels of AGEs have been shown in tissues of diabetes
    patients and in several different cell structures of the eye in distinct ocular disorders. AGEs can be
    assessed non-invasively in the skin due to fluorescent properties of several AGEs. This technique, also
    referred to as skin autofluorescence (SAF), has been used to assess AGE accumulation in the skin.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Smit, Andries, Supervisor
    • Hooymans, Johanna M.M., Supervisor
    • Mulder, Udo, Co-supervisor
    • Los, Leonie, Co-supervisor
    Award date13-Nov-2017
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-0130-0
    Electronic ISBNs978-94-034-0129-4
    Publication statusPublished - 2017

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