Diabetic Foot Infections: The Diagnostic Challenges

Chiara Lauri*, Antonio Leone, Marco Cavallini, Alberto Signore, Laura Giurato, Luigi Uccioli

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

    30 Downloads (Pure)

    Abstract

    Diabetic foot infections (DFIs) are severe complications of long-standing diabetes, and they represent a diagnostic challenge, since the differentiation between osteomyelitis (OM), soft tissue infection (STI), and Charcot's osteoarthropathy is very difficult to achieve. Nevertheless, such differential diagnosis is mandatory in order to plan the most appropriate treatment for the patient. The isolation of the pathogen from bone or soft tissues is still the gold standard for diagnosis; however, it would be desirable to have a non-invasive test that is able to detect, localize, and evaluate the extent of the infection with high accuracy. A multidisciplinary approach is the key for the correct management of diabetic patients dealing with infective complications, but at the moment, no definite diagnostic flow charts still exist. This review aims at providing an overview on multimodality imaging for the diagnosis of DFI and to address evidence-based answers to the clinicians when they appeal to radiologists or nuclear medicine (NM) physicians for studying their patients.

    Original languageEnglish
    Article number1779
    Number of pages20
    JournalJournal of Clinical Medicine
    Volume9
    Issue number6
    DOIs
    Publication statusPublished - Jun-2020

    Keywords

    • infection
    • diabetic foot
    • imaging
    • WBC scintigraphy
    • [F-18]FDG PET/CT
    • MRI
    • BLOOD-CELL SCINTIGRAPHY
    • TO-BONE TEST
    • IMAGE ACQUISITION
    • UNSUSPECTED OSTEOMYELITIS
    • INTERPRETATION CRITERIA
    • PEDAL OSTEOMYELITIS
    • LABELED LEUKOCYTE
    • IN-111 LEUKOCYTE
    • DISEASES SOCIETY
    • SPECT/CT

    Cite this