Diagnosis and antimicrobial therapy of Mycoplasma hominis meningitis in adults

Elisabeth H. L. Lee*, Heinrich L. J. Winter, Jan Maarten van Dijl, Joannes D. M. Metzemaekers, Jan P. Arends

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

14 Citations (Scopus)

Abstract

Meningitis in adults due to infection with Mycoplasma hominis is rarely reported. Here, we document the third case of M. hominis meningitis in an adult individual, developed upon neurosurgery following a subarachnoid haemorrhage. Our findings are noteworthy, because the presence of M. hominis in cerebrospinal fluid cannot be identified by standard culturing, Gram-staining, or matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Importantly, however, 16S rDNA sequencing did lead to an unambiguous diagnosis and guided successful antimicrobial therapy. Based on our present findings and a review of the respective literature, we conclude that M. hominis should be considered as a candidate causative agent of infections of the central nervous system following neurosurgical procedures, especially if there is no response to standard antimicrobial therapy, and routine culturing yields negative results. (C) 2012 Elsevier GmbH. All rights reserved.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalInternational journal of medical microbiology
Volume302
Issue number7-8
DOIs
Publication statusPublished - Dec-2012

Keywords

  • Mycoplasma hominis
  • Meningitis
  • Central nervous system
  • 16S rDNA sequencing
  • Antimicrobial therapy
  • CEREBROSPINAL-FLUID
  • BRAIN-ABSCESS
  • INFECTION
  • CLINDAMYCIN
  • PENETRATION
  • CULTURES

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