TY - JOUR
T1 - Dietary Intake Pattern is Associated with Occurrence of Flares in IBD Patients
AU - Peters, Vera
AU - Spooren, Corinne
AU - Pierik, Marie
AU - Weersma, Rinse
AU - van Dullemen, Hendrik
AU - Festen, Eleonora
AU - Visschedijk, Marijn
AU - Masclee, Adriaan
AU - Hendrix, Evelien
AU - Almeida, Rui
AU - Perenboom, Corine
AU - Feskens, Edith
AU - Dijkstra, Gerard
AU - Campmans-Kuijpers, Marjo
AU - Jonkers, Daisy
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].
PY - 2021/8
Y1 - 2021/8
N2 - BACKGROUND: Diet is associated with onset of inflammatory bowel disease (IBD). Up to half of IBD patients believe that diet contributes to flares. However, studies on this topic are sparse and merely focus on specific nutrients, food items or food groups. We aimed to analyze the association between dietary patterns and flare occurrence in two geographically distinct Dutch cohorts.METHODS: In this longitudinal study, 724 IBD patients (Northern cohort: n=486, Southern cohort: n=238) were included and followed for two years. Habitual dietary intake was obtained via semi-quantitative food frequency questionnaires at baseline. Principal component analysis (PCA) was conducted on 22 food groups to identify dietary patterns. Flare occurrence was analyzed in 427 patients in remission at baseline, using multivariable COX proportional hazards.RESULTS: Compared to the Southern cohort, patients in the Northern cohort were younger at diagnosis, comprised more females, and had lower overall energy intakes (all p<0.05). PCA revealed three dietary patterns explaining 28.8% of the total variance. The most pronounced pattern (explaining 11.6%) was characterized by intake of grain products, oils, potatoes, processed meat, red meat, condiments and sauces, and sugar, cakes and confectionery. Of the 427 patients, 106 (24.8%) developed an exacerbation during follow-up. The above dietary pattern was associated with flare occurrence (HR: 1.51, 95% CI: 1.04-2.18, p=0.029), as was female sex (HR: 1.63, 95% CI 1.04-2.55, p=0.032).CONCLUSIONS: A dietary pattern, which can be seen as a "traditional (Dutch)" or "Western" pattern was associated with flare occurrence. Confirmation in prospective studies is needed.
AB - BACKGROUND: Diet is associated with onset of inflammatory bowel disease (IBD). Up to half of IBD patients believe that diet contributes to flares. However, studies on this topic are sparse and merely focus on specific nutrients, food items or food groups. We aimed to analyze the association between dietary patterns and flare occurrence in two geographically distinct Dutch cohorts.METHODS: In this longitudinal study, 724 IBD patients (Northern cohort: n=486, Southern cohort: n=238) were included and followed for two years. Habitual dietary intake was obtained via semi-quantitative food frequency questionnaires at baseline. Principal component analysis (PCA) was conducted on 22 food groups to identify dietary patterns. Flare occurrence was analyzed in 427 patients in remission at baseline, using multivariable COX proportional hazards.RESULTS: Compared to the Southern cohort, patients in the Northern cohort were younger at diagnosis, comprised more females, and had lower overall energy intakes (all p<0.05). PCA revealed three dietary patterns explaining 28.8% of the total variance. The most pronounced pattern (explaining 11.6%) was characterized by intake of grain products, oils, potatoes, processed meat, red meat, condiments and sauces, and sugar, cakes and confectionery. Of the 427 patients, 106 (24.8%) developed an exacerbation during follow-up. The above dietary pattern was associated with flare occurrence (HR: 1.51, 95% CI: 1.04-2.18, p=0.029), as was female sex (HR: 1.63, 95% CI 1.04-2.55, p=0.032).CONCLUSIONS: A dietary pattern, which can be seen as a "traditional (Dutch)" or "Western" pattern was associated with flare occurrence. Confirmation in prospective studies is needed.
U2 - 10.1093/ecco-jcc/jjab008
DO - 10.1093/ecco-jcc/jjab008
M3 - Article
C2 - 33439251
SN - 1873-9946
VL - 15
SP - 1305
EP - 1315
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 8
ER -