Dietary phytoestrogen intake and cognitive function in older women

Sanne Kreijkamp-Kaspers, Linda Kok, Diederick E. Grobbee, Edward H. F. de Haan, Andre Aleman, Yvonne T. van der Schouw*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

Background. Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline.

Methods. We conducted a cross-sectional study in 301 Dutch women aged 60-75 years. Dietary isoflavone and lignan intake was assessed with a food-frequency questionnaire covering habitual diet in the year preceding enrolment. The endpoints were cognitive function measured in three domains: memory, processing capacity and speed, and executive function. Data were analyzed using linear regression models, after adjusting for confounders.

Results. No association between dietary isoflavone intake and cognitive function was found. High lignan intake was associated with a better performance in processing capacity and speed, and in executive function (p for trend over quartiles =.01 and.02, respectively).

Conclusions. This finding calls for further research to elucidate the relatively underexplored role of lignans within the range of phytoestrogens.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalJournals of Gerontology Series A-Biological Sciences and Medical Sciences
Volume62
Issue number5
Publication statusPublished - May-2007

Keywords

  • POSTMENOPAUSAL WOMEN
  • SOY PROTEIN
  • ISOFLAVONES
  • DEMENTIA
  • MEMORY
  • TRIAL
  • METAANALYSIS
  • SPECIFICITY
  • IMPAIRMENT
  • THERAPY

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