Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma

Sanne Evelien Matlung; Pauline Maria Wilhelmina van Kempen; Niels Bovenschen; Debbie van Baarle; Stefan Martin Willems

doi:10.4155/fso.15.88

Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma

Sanne Evelien Matlung, Pauline Maria Wilhelmina van Kempen, Niels Bovenschen, Debbie van Baarle, Stefan Martin Willems^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

32 Downloads (Pure)

Abstract

Recent studies have suggested that immune cells as part of tumor's microenvironment could partly explain the better outcome in HPV-associated oropharyngeal carcinoma. We performed a systematic review of the literature focused on differences in immune-infiltrate in HPV+ versus HPV- oropharyngeal cancers. This comprehensive search yielded 4308 original papers, of which 20 satisfied our eligibility criteria. Increase in both circulating and tumor infiltrating CD8+ lymphocytes is mainly seen in HPV+ oropharyngeal carcinoma. Interestingly, the survival benefit associated with increase in immune cells is equal both in HPV+ and HPV- oropharyngeal cancer. Based on these results, our review underscores the role of the immune system in the biological and clinical behavior of oropharyngeal squamous cell carcinomas (OPSCC) and might open doors to further investigate immune modulatory treatment options in OPSCC patients.

Original language	English
Pages (from-to)	FSO88
Journal	Future Bright
Volume	2
Issue number	1
DOIs	https://doi.org/10.4155/fso.15.88
Publication status	Published - 2016
Externally published	Yes

Access to Document

10.4155/fso.15.88Licence: CC BY

Differences in T-cell infiltrates and survivalFinal publisher's version, 576 KBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{c66390a5089748de9f76dfe3c5b21e04,

title = "Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma",

abstract = "Recent studies have suggested that immune cells as part of tumor's microenvironment could partly explain the better outcome in HPV-associated oropharyngeal carcinoma. We performed a systematic review of the literature focused on differences in immune-infiltrate in HPV+ versus HPV- oropharyngeal cancers. This comprehensive search yielded 4308 original papers, of which 20 satisfied our eligibility criteria. Increase in both circulating and tumor infiltrating CD8+ lymphocytes is mainly seen in HPV+ oropharyngeal carcinoma. Interestingly, the survival benefit associated with increase in immune cells is equal both in HPV+ and HPV- oropharyngeal cancer. Based on these results, our review underscores the role of the immune system in the biological and clinical behavior of oropharyngeal squamous cell carcinomas (OPSCC) and might open doors to further investigate immune modulatory treatment options in OPSCC patients.",

author = "Matlung, {Sanne Evelien} and {Wilhelmina van Kempen}, {Pauline Maria} and Niels Bovenschen and {van Baarle}, Debbie and Willems, {Stefan Martin}",

year = "2016",

doi = "10.4155/fso.15.88",

language = "English",

volume = "2",

pages = "FSO88",

journal = "Future Bright",

issn = "2056-5623",

number = "1",

}

TY - JOUR

T1 - Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma

AU - Matlung, Sanne Evelien

AU - Wilhelmina van Kempen, Pauline Maria

AU - Bovenschen, Niels

AU - van Baarle, Debbie

AU - Willems, Stefan Martin

PY - 2016

Y1 - 2016

N2 - Recent studies have suggested that immune cells as part of tumor's microenvironment could partly explain the better outcome in HPV-associated oropharyngeal carcinoma. We performed a systematic review of the literature focused on differences in immune-infiltrate in HPV+ versus HPV- oropharyngeal cancers. This comprehensive search yielded 4308 original papers, of which 20 satisfied our eligibility criteria. Increase in both circulating and tumor infiltrating CD8+ lymphocytes is mainly seen in HPV+ oropharyngeal carcinoma. Interestingly, the survival benefit associated with increase in immune cells is equal both in HPV+ and HPV- oropharyngeal cancer. Based on these results, our review underscores the role of the immune system in the biological and clinical behavior of oropharyngeal squamous cell carcinomas (OPSCC) and might open doors to further investigate immune modulatory treatment options in OPSCC patients.

AB - Recent studies have suggested that immune cells as part of tumor's microenvironment could partly explain the better outcome in HPV-associated oropharyngeal carcinoma. We performed a systematic review of the literature focused on differences in immune-infiltrate in HPV+ versus HPV- oropharyngeal cancers. This comprehensive search yielded 4308 original papers, of which 20 satisfied our eligibility criteria. Increase in both circulating and tumor infiltrating CD8+ lymphocytes is mainly seen in HPV+ oropharyngeal carcinoma. Interestingly, the survival benefit associated with increase in immune cells is equal both in HPV+ and HPV- oropharyngeal cancer. Based on these results, our review underscores the role of the immune system in the biological and clinical behavior of oropharyngeal squamous cell carcinomas (OPSCC) and might open doors to further investigate immune modulatory treatment options in OPSCC patients.

U2 - 10.4155/fso.15.88

DO - 10.4155/fso.15.88

M3 - Review article

C2 - 28031938

SN - 2056-5623

VL - 2

SP - FSO88

JO - Future Bright

JF - Future Bright

IS - 1

ER -

Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma

Abstract

Access to Document

Handle.net

Fingerprint

Cite this