Different homing pattern of isolated mouse lymphoma cells correlates with a different chromosomal pattern

R.J van Berlo*, B de Jong, W.M Molenaar, W Lemstra , Jelleke Dokter, T Dijkhuizen, Joke Wierda, T.W.T Konings

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    After 5–20 weeks of in vitro culture of mouse lymphoma cells, a characteristic and reproducible change in cell morphology, clonogenic ability, and homing pattern after intraperitoneal or intravenous injection was observed. Cytogenetic comparison of the two cell populations present before and after the “switch” revealed that the phenotypic changes cannot be due to in vitro karyotype evolution because their chromosomal pattern differed in such a way that it is impossible that they can evolve from each other. It was concluded that two different cell populations are present in the lymphoma and their growth and behavior are influenced by certain circumstances and/or interactions. Apparently one population predominates in the peripheral blood circulation, whereas the other will predominate after prolonged in vitro culturing
    Original languageEnglish
    Pages (from-to)33-42
    Number of pages10
    JournalCancer Genetics and Cytogenetics
    Issue number1
    Publication statusPublished - Mar-1989

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