Abstract
The sphingolipid composition and multidrug resistance status of three human neuroblastoma cell lines were established. SK-N-FI cells displayed high expression and functional (efflux) activity of P-glycoprotein, while multidrug resistance-related protein 1 was relatively abundant and most active in SK-N-AS cells. These two cell lines exhibited higher sphingolipid levels, compared to SK-N-DZ, which had the lowest activity of either ATP-binding cassette transporter protein. SK-N-DZ cells also differed in ganglioside composition with predominant expression of b-series gangliosides. In conclusion, these three neuroblastoma cell lines offer a good model system to study sphingolipid metabolism in relation to ATP-binding cassette transporter protein function. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
| Original language | English |
|---|---|
| Pages (from-to) | 28-32 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 548 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 31-Jul-2003 |
Keywords
- neuroblastoma
- sphingolipid
- ganglioside
- multidrug resistance
- P-glycoprotein
- multidrug resistance-related protein 1
- CANCER-CELLS
- CERAMIDE
- GLUCOSYLCERAMIDE
- METABOLISM
- LEUKEMIA
- PATTERN