Diffusion tensor Imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy

P. E. Sijens*, Martinus Heesters, Roeline Enting, W. T. A. van der Graaf, J. H. Potze, Roy Irwan, L. C. Meiners, M. Oudkerk

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy. Tumor shrinkage was paralleled by reductions in choline level and by increases in apparent diffusion coefficient indicating decreased cellularity. Within the tumor, choline level and apparent diffusion coefficient showed a significant inverse correlation (P <0.01). Fractional anisotropy distribution in the tumor correlated positively with N-acetyl aspartate level (P <0.001), indicating that these parameters reflect (remaining) axonal structure. Tumor lactate level, also found to decrease under therapy, did not correlate with any other parameter.

    Original languageEnglish
    Pages (from-to)706-710
    Number of pages5
    JournalCancer Investigation
    Volume25
    Issue number8
    DOIs
    Publication statusPublished - Dec-2007

    Keywords

    • brain tumor
    • glioma
    • diffusion tensor imaging
    • magnetic resonance spectroscopy
    • PROTON MR SPECTROSCOPY
    • BRAIN-TUMORS
    • PERFUSION

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