Diffusion tensor imaging and magnetic resonance spectroscopy of the brain in a patient with Sturge-Weber syndrome

P. E. Sijens*, E. W. Gieteling, L. C. Meiners, D. A. Sival, J. H. Potze, R. Irwan, M. Oudkerk

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    Quantitative brain MR spectroscopy (MRS) and diffusion tensor imaging (DTI) were used to characterize one patient with Sturge-Weber syndrome. Choline increases and N-acetylaspartate decreases were observed in pathologic frontal gray matter tissue compared to contralateral unaffected brain tissue without any change in the diffusion tensor imaging parameters (fractional anisotropy, apparent diffusion coefficient). The N-acetylaspartate decreases and/or choline increases observed here and in eight previously described Sturge-Weber patients probably reflect neuronal loss or dysfunction and demyelination as a result of recurrent seizures.

    Original languageEnglish
    Pages (from-to)972-976
    Number of pages5
    JournalActa Radiologica
    Volume47
    Issue number9
    DOIs
    Publication statusPublished - Nov-2006

    Keywords

    • brain metabolism
    • diffusion tensor imaging
    • epilepsy
    • magnetic resonance spectroscopy
    • Sturge-Weber syndrome
    • MR SPECTROSCOPY
    • CHILDREN

    Cite this