Diminished counterregulatory responses to meal-induced hypoglycemia 4 years after RYGB

Loek J.M. de Heide*, Merel van den Broek, Gertjan van Dijk, Marloes Emous, André P. van Beek

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Abstract

PURPOSE: Post-bariatric hypoglycemia is a complication of bariatric surgery, especially Roux-en-Y gastric bypass (RYGB). The counterregulatory hormonal and sympathetic neural responses were measured during a previously reported meal test in which 48% had an almost asymptomatic hypoglycemic event.

MATERIALS AND METHODS: Forty-four randomly selected patients 4 years after RYGB. A liquid meal test (MMT) after overnight fasting. Based on the glucose nadir during the MMT, patients were divided in a hypo group (glucose < 3.3 mmol/L) and a non-hypo group (glucose ≥ 3.3 mmol/L). Cortisol, epinephrine, norepinephrine, blood pressure, and heart rate were measured up to 180 min after ingestion of the meal. Incremental areas under the curve (iAUC), peak, and delta hormone responses after the glucose nadir were calculated. Parameters were compared between the hypo and non-hypo groups.

RESULTS: A total of 21/44 (48%) had an almost asymptomatic hypoglycemic event. Cortisol and epinephrine responses in the hypo group were not increased compared to the non-hypo group, and there were no signs of increased sympathetic nerve activity. Peak and delta cortisol were lower in the hypo compared to the non-hypo group. Norepinephrine was higher in the hypo group especially in the time frame 60-120 and 120-180 min after start of the meal.

CONCLUSION: No increase in epinephrine and a lower cortisol response to hypoglycemia were observed compared to normoglycemia during a meal test in patients after RYGB. Norepinephrine levels were higher in the hypo group. These findings may suggest that possible recurrent hypoglycemia after RYGB results in blunting of counterregulatory responses indicative of hypoglycemia-induced autonomic failure.

CLIN TRIAL REGISTER ID: ISRCTN 11738149.

Original languageEnglish
Pages (from-to)597–602
Number of pages6
JournalObesity Surgery
Volume31
Issue number2
Early online date16-Oct-2020
DOIs
Publication statusPublished - Feb-2021

Keywords

  • GASTRIC-BYPASS-SURGERY
  • HYPERINSULINEMIC HYPOGLYCEMIA
  • ANTECEDENT HYPOGLYCEMIA
  • SUBSEQUENT HYPOGLYCEMIA
  • AUTONOMIC FAILURE
  • MECHANISMS

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