Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease

RC Klein, BM de Jong*, JJ de Vries, KL Leenders

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    30 Citations (Scopus)

    Abstract

    The differentiation between progressive supranuclear palsy (PSP) and Parkinson's disease (PD) may be difficult, especially in the early stages of disease. Positron emission tomography potentially provides a tool for making such a distinction. To identify key features in the spatial distributions of cerebral glucose metabolism, F-18-fluorodeoxyglucose (FDG) measurements of 10 patients with probable or possible PSP were directly compared with those of 9 PD patients. This analysis was done with statistic parametric mapping. After normalization of global brain uptake, in PSP, relative uptake of FDG was reduced in the caudal (motor) part of the anterior cingulate gyrus (Brodmann's area BA 24; P <0.05, corrected for multiple comparisons). At a lower threshold, an additional decrease was present in the dorsal inesencephalon. In PD, relative hypometabolism was seen in extrastriate visual, ventrolateral temporal, posterior parietal, and orbitofrontal regions. Only reduction in the right fusiform gyrus and the lateral extrastriate visual cortex reached statistical significance. We concluded that particularly the reduction of medial frontal metabolism may be a valuable diagnostic imaging parameter in distinguishing PSP from PD. For PD, a possible association between occipitoternporal FDG decrease and vulnerability to hallucinations is suggested. (c) 2005 Movement Disorder Society.

    Original languageEnglish
    Pages (from-to)1021-1030
    Number of pages10
    JournalMovement Disorders
    Volume20
    Issue number8
    DOIs
    Publication statusPublished - Aug-2005

    Keywords

    • progressive supranuclear palsy
    • Parkinson's disease
    • PET
    • FDG
    • SPM
    • medial frontal metabolism
    • hallucination
    • cingulate gyrus
    • POSITRON EMISSION TOMOGRAPHY
    • RICHARDSON-OLSZEWSKI-SYNDROME
    • GLUCOSE-METABOLISM
    • CORTICOBASAL DEGENERATION
    • CORTICAL DYSFUNCTION
    • ANTERIOR CINGULATE
    • HUMAN-BRAIN
    • BLOOD-FLOW
    • HYPOMETABOLISM
    • CORTEX

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