Direct comparison of oscillatory activity in the motor system of Parkinson's disease and dystonia: A review of the literature and meta-analysis

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Objective: To outline the current knowledge of (sub) cortical oscillations in Parkinson's Disease (PD) and dystonia, and to quantitatively summarize the results of direct comparisons of local oscillatory power between both diseases in the resting state, without medication or stimulation, in both the lowfrequency (LF, +/- 4-12 Hz) and beta (+/- 13 to similar to 30 Hz) range.

Methods: Eight relevant studies were included. Recordings from 127 dystonia-, and 144 PD-patient hemispheres were analyzed. Ratios of LF and beta power between diseases were obtained.

Results: Beta oscillations in dystonia were lower when compared to beta oscillations in PD, ratio = 0.72, Z = 3.56, p = 0.0004, 95% CI [0.60, 0.86]. Subgroup analyses showed significant differences only in the GPi, whilst conflicting evidence was shown in the STN. LF oscillations in PD were lower when compared to LF oscillations in dystonia, ratio = 0.77, Z = 2.45, p = 0.01, 95% CI [0.63, 0.95]. Subgroup analyses showed significant differences in the GPi and the STN, but not in the M1.

Conclusions: LF and beta oscillations are present in the resting-state motor network of both PD and dystonia patients. However, the power distribution of those oscillations differs between diseases.

Significance: This meta-analysis provides high-level evidence which supports the presence of exaggerated oscillations across the parkinsonian/dystonic motor networks. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)917-924
Number of pages8
JournalClinical Neurophysiology
Volume130
Issue number6
Early online date2019
DOIs
Publication statusPublished - Jun-2019

Keywords

  • Parkinson's disease
  • Dystonia
  • Deep brain stimulation
  • Neural oscillations
  • Local field potentials
  • Beta oscillations
  • Low-frequency oscillations
  • DEEP-BRAIN-STIMULATION
  • GLOBUS-PALLIDUS INTERNUS
  • LOCAL-FIELD POTENTIALS
  • SUBTHALAMIC NUCLEUS
  • SENSORIMOTOR-CORTEX
  • NEURONAL-ACTIVITY
  • MUSCLE-ACTIVITY
  • BASAL GANGLIA
  • EMG ACTIVITY
  • MOVEMENT

Cite this