Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores

Nicole Stéphanie Galenkamp, Misha Soskine, Jos Hermans, Carsten Wloka, Giovanni Maglia

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Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.
Original languageEnglish
Article number4085
Number of pages8
JournalNature Communications
Issue number1
Publication statusPublished - 5-Oct-2018


  • biological nanopores

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