Directed evolution of synthetic coexistence: A new path towards ecosystem design?

Sonja Billerbeck*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In nature, microorganisms never live alone but rather build interconnected communities, able to perform complex biochemical tasks that are essential to the function of most of earth’s ecosystems. By comparison, the microorganisms we rely on as chassis for synthetic biology lead relatively simple, isolated lives. However, mimicking the natural complexity of microbiomes can help synthetic biologists realize more advanced functionalities; e.g. as shown for the efficient biosynthesis of oxygenated taxanes (precursors of the antitumor agent paclitaxel) in a two-species ecosystem (1).
Original languageEnglish
Article numberysaa025
Number of pages2
JournalSynthetic biology (Oxford, England)
Volume5
Issue number1
DOIs
Publication statusPublished - 24-Nov-2020

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