TY - JOUR
T1 - Disadvantage of Small (<60 kg) Adult Candidates on the Liver Transplantation Waitlist
AU - van Dijk, Anne Baue R.M.
AU - Sneiders, Dimitri
AU - Murad, Sarwa Darwish
AU - Polak, Wojciech G.
AU - Hartog, Hermien
N1 - Publisher Copyright:
© NATCO: The Organization for Transplant Professionals 2020.
PY - 2020/12
Y1 - 2020/12
N2 - Background: Small adult patients with lower bodyweight wait-listed for liver transplantation may face a shortage of size-matched whole-liver grafts. The objective of this study is to compare time to transplantation in adult patients with a bodyweight of <60 kg to patients with bodyweight ≥60 kg.Methods: A matched case–control study was conducted. Patients aged 18 years and older listed for liver transplantation at our transplant center, from 2007 to 2016 with a bodyweight <60 kg were manually matched 1:2 to control patients ≥ 60 kg. Matching was performed based on ABO blood type, model for end-stage liver disease score, (non)-standard exception status, and eligibility for donation after cardiac death. Time to transplantation was assessed with univariable Cox-regression.Results: In total, 23 cases with a bodyweight < 60 kg were matched to 46 average-sized control patients. Small adults were significantly disadvantaged for receiving a liver transplantation as compared to their average-sized counterpart (hazard ratio 0.47; 95% confidence interval 0.29-0.75, P =.002). At the end of follow-up, 14/23 (60.9%) of cases versus 35/46 of controls (76.1%) had received a liver transplantation.Conclusion: Small adults with a bodyweight below 60 kg are disadvantaged on the waitlist for a size-matched whole liver graft.
AB - Background: Small adult patients with lower bodyweight wait-listed for liver transplantation may face a shortage of size-matched whole-liver grafts. The objective of this study is to compare time to transplantation in adult patients with a bodyweight of <60 kg to patients with bodyweight ≥60 kg.Methods: A matched case–control study was conducted. Patients aged 18 years and older listed for liver transplantation at our transplant center, from 2007 to 2016 with a bodyweight <60 kg were manually matched 1:2 to control patients ≥ 60 kg. Matching was performed based on ABO blood type, model for end-stage liver disease score, (non)-standard exception status, and eligibility for donation after cardiac death. Time to transplantation was assessed with univariable Cox-regression.Results: In total, 23 cases with a bodyweight < 60 kg were matched to 46 average-sized control patients. Small adults were significantly disadvantaged for receiving a liver transplantation as compared to their average-sized counterpart (hazard ratio 0.47; 95% confidence interval 0.29-0.75, P =.002). At the end of follow-up, 14/23 (60.9%) of cases versus 35/46 of controls (76.1%) had received a liver transplantation.Conclusion: Small adults with a bodyweight below 60 kg are disadvantaged on the waitlist for a size-matched whole liver graft.
KW - allocation
KW - liver transplant recipient
KW - liver transplantation
KW - waitlist
KW - waitlist allocation
UR - https://www.scopus.com/pages/publications/85090868827
U2 - 10.1177/1526924820958142
DO - 10.1177/1526924820958142
M3 - Article
C2 - 32912082
AN - SCOPUS:85090868827
SN - 1526-9248
VL - 30
SP - 349
EP - 354
JO - Progress in transplantation
JF - Progress in transplantation
IS - 4
ER -