Discovery of Inhibitors by Combinatorial-Chemistry Approaches

Ramon van der Vlag

doi:10.33612/diss.146091529

Discovery of Inhibitors by Combinatorial-Chemistry Approaches

Ramon van der Vlag

Chemical Biology 2

Research output: Thesis › Thesis fully internal (DIV)

388 Downloads (Pure)

Abstract

This thesis describes our efforts to develop inhibitors using combinatorial-chemistry approaches. These approaches can potentially speed-up the drug discovery trajectory and the discovered molecules could be used as starting points for future drug development projects targeting 15-LOX-1, MIF and/or MDM2. The aforementioned targets are all proteins that play an important role in common diseases.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Hirsch, Anna, Supervisor Dekker, Frank, Supervisor
Award date	27-Nov-2020
Place of Publication	[Groningen]
Publisher	University of Groningen
DOIs	https://doi.org/10.33612/diss.146091529
Publication status	Published - 2020

Access to Document

10.33612/diss.146091529

Title and contentsFinal publisher's version, 213 KB
Chapter 1Final publisher's version, 1.43 MB
Chapter 2Final publisher's version, 1.42 MB
Chapter 3Final publisher's version, 718 KB
Chapter 4Final publisher's version, 1.3 MB
Chapter 5Final publisher's version, 2.04 MB
Chapter 6Final publisher's version, 327 KB
Chapter 7Final publisher's version, 340 KB
Chapter 8Final publisher's version, 216 KB
Complete thesisFinal publisher's version, 7.32 MB
PropositionsFinal publisher's version, 171 KB

Cite this

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AB - This thesis describes our efforts to develop inhibitors using combinatorial-chemistry approaches. These approaches can potentially speed-up the drug discovery trajectory and the discovered molecules could be used as starting points for future drug development projects targeting 15-LOX-1, MIF and/or MDM2. The aforementioned targets are all proteins that play an important role in common diseases.

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M3 - Thesis fully internal (DIV)

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