Discovery of Inhibitors by Combinatorial-Chemistry Approaches

Ramon van der Vlag

Research output: ThesisThesis fully internal (DIV)

182 Downloads (Pure)

Abstract

This thesis describes our efforts to develop inhibitors using combinatorial-chemistry approaches. These approaches can potentially speed-up the drug discovery trajectory and the discovered molecules could be used as starting points for future drug development projects targeting 15-LOX-1, MIF and/or MDM2. The aforementioned targets are all proteins that play an important role in common diseases.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Hirsch, Anna, Supervisor
  • Dekker, Frank, Supervisor
Award date27-Nov-2020
Place of Publication[Groningen]
Publisher
DOIs
Publication statusPublished - 2020

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