Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang, Kelly Rootes-Murdy*, Kuaikuai Duan, Gido Schoenmacker, Pieter J Hoekstra, Catharina A Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Emma Sprooten, Jan Buitelaar, Alejandro Arias-Vasquez, Jingyu Liu, Jessica A Turner

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Original languageEnglish
Article number111282
JournalPsychiatry research-Neuroimaging
Publication statusPublished - 30-May-2021

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