Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

Maarten J ten Berg; Albert Huisman; Patricia M L A van den Bemt; Hanneke den Breeijen; Toine C G Egberts; Wouter W van Solinge

doi:10.3109/1354750X.2010.526243

Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

Maarten J ten Berg
, Albert Huisman
, Patricia M L A van den Bemt
, Hanneke den Breeijen
, Toine C G Egberts
, Wouter W van Solinge^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.

OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.

MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.

RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

Original language	English
Pages (from-to)	51-7
Number of pages	7
Journal	Biomarkers
Volume	16
Issue number	1
DOIs	https://doi.org/10.3109/1354750X.2010.526243
Publication status	Published - Feb-2011
Externally published	Yes

Keywords

Adult
Aged
Antineoplastic Agents/adverse effects
Biomarkers, Pharmacological/blood
Blood Platelets/pathology
Cell Size/drug effects
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Male
Middle Aged
Neoplasms/drug therapy
Platelet Count
Retrospective Studies
Thrombocytopenia/chemically induced

Access to Document

10.3109/1354750X.2010.526243

Handle.net

Persistent link

Embargoed Document

Discriminative value of platelet size indices for the identification of the mechanism of chemotherap
Final publisher's version, 729 KB
Request copy

Cite this

@article{b35ffb309ef746598015883975fb2246,

title = "Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia",

abstract = "CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.",

keywords = "Adult, Aged, Antineoplastic Agents/adverse effects, Biomarkers, Pharmacological/blood, Blood Platelets/pathology, Cell Size/drug effects, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Male, Middle Aged, Neoplasms/drug therapy, Platelet Count, Retrospective Studies, Thrombocytopenia/chemically induced",

author = "\{ten Berg\}, \{Maarten J\} and Albert Huisman and \{van den Bemt\}, \{Patricia M L A\} and \{den Breeijen\}, Hanneke and Egberts, \{Toine C G\} and \{van Solinge\}, \{Wouter W\}",

year = "2011",

month = feb,

doi = "10.3109/1354750X.2010.526243",

language = "English",

volume = "16",

pages = "51--7",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor \& Francis Group",

number = "1",

}

TY - JOUR

T1 - Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

AU - ten Berg, Maarten J

AU - Huisman, Albert

AU - van den Bemt, Patricia M L A

AU - den Breeijen, Hanneke

AU - Egberts, Toine C G

AU - van Solinge, Wouter W

PY - 2011/2

Y1 - 2011/2

N2 - CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

AB - CONTEXT: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.OBJECTIVE: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.MATERIALS AND METHODS: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.RESULTS AND CONCLUSIONS: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

KW - Adult

KW - Aged

KW - Antineoplastic Agents/adverse effects

KW - Biomarkers, Pharmacological/blood

KW - Blood Platelets/pathology

KW - Cell Size/drug effects

KW - Drug-Related Side Effects and Adverse Reactions

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms/drug therapy

KW - Platelet Count

KW - Retrospective Studies

KW - Thrombocytopenia/chemically induced

U2 - 10.3109/1354750X.2010.526243

DO - 10.3109/1354750X.2010.526243

M3 - Article

C2 - 20977409

SN - 1354-750X

VL - 16

SP - 51

EP - 57

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -

Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

Abstract

Keywords

Access to Document

Handle.net

Embargoed Document

Fingerprint

Cite this