Disease managing capacities and mechanisms of host effects of lactic acid bacteria

Chengcheng Ren*, Marijke M Faas, Paul de Vos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Consumption of lactic acid bacteria (LAB) has been suggested to confer health-promoting effects on the host. However, effects of LABs have been reported to be species- and strain-specific and the mechanisms involved are subjects of discussion. Here, the possible mechanisms by which LABs induce antipathogenic, gut barrier enhancing and immune modulating effects in consumers are reviewed. Specific strains for which it has been proven that health is improved by these mechanisms are discussed. However, most strains probably act via several or combinations of mechanisms depending on which effector molecules they express. Current insight is that these effector molecules are either present on the cell wall of LAB or are excreted. These molecules are reviewed as well as the ligand binding receptors in the host. Also postbiotics are discussed. Finally, we provide an overview of the efficacy of LABs in combating infections caused by Helicobacter pylori, Salmonella, Escherichia coli, Streptococcus pneumoniae, and influenza virus, in controlling gut inflammatory diseases, in managing allergic disorders, and in alleviating cancer.

Original languageEnglish
Pages (from-to)1365-1393
Number of pages29
JournalCritical Reviews in Food Science and Nutrition
Volume61
Issue number8
Early online date2020
DOIs
Publication statusPublished - Apr-2021

Keywords

  • Beneficial function
  • gut barrier
  • gut microbiota
  • immune modulation
  • lactic acid bacteria
  • mechanism
  • LACTOBACILLUS-RHAMNOSUS GG
  • INFLUENZA-VIRUS INFECTION
  • PNEUMOCOCCAL RESPIRATORY-INFECTION
  • HELICOBACTER-PYLORI COLONIZATION
  • INTESTINAL EPITHELIAL-CELLS
  • RANDOMIZED CLINICAL-TRIAL
  • MUCOSAL POUCH MICROBIOTA
  • TOLL-LIKE RECEPTORS
  • 1ST 6 MONTHS
  • DOUBLE-BLIND

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