Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors

Maximilian Lassi, Archana Tomar, Gemma Comas-Armangué, Rebekka Vogtmann, Dorieke J Dijkstra, David Corujo, Raffaele Gerlini, Jonatan Darr, Fabienne Scheid, Jan Rozman, Antonio Aguilar-Pimentel, Omry Koren, Marcus Buschbeck, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Martin Hrabe de Angelis, Torsten Plösch, Alexandra Gellhaus, Raffaele Teperino*

*Corresponding author for this work

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Abstract

Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.

Original languageEnglish
Article number6424
Number of pages13
JournalScience Advances
Volume7
Issue number22
DOIs
Publication statusPublished - 26-May-2021

Keywords

  • FETAL-GROWTH
  • SEX-DIFFERENCES
  • GLUCOCORTICOIDS
  • CLOCKS
  • MOUSE
  • RESTRICTION
  • OBESITY
  • RESPONSES
  • HORMONES
  • STRESS

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