Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease

Int Parkinson's Dis Genomics Conso, Maren Stolp Andersen, Manuela Tan, Inge R. Holtman, John Hardy, Lasse Pihlstrom*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
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Abstract

Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies. Evidence for genetic overlap is limited, although enrichment of heritability in genomic regions relevant to microglia has been demonstrated in both disorders. Using summary statistics from genome-wide association studies, we assessed genetic covariance stratified by cell types and local genetic correlation between Parkinson's and Alzheimer's disease. Significant covariance was observed for neurons only (p = 0.00046), and local genetic correlation was significant only in the human leukocyte antigen region (p = 1.0e-05). Our findings support a minor genetic overlap between these two disorders.

Original languageEnglish
Pages (from-to)1289-1295
Number of pages7
JournalAnnals of Clinical and Translational Neurology
Volume9
Issue number8
Early online date9-Jun-2022
DOIs
Publication statusPublished - 2022

Keywords

  • GENOME-WIDE ASSOCIATION
  • RISK LOCI
  • INSIGHTS
  • IMPACT

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