Abstract
The rotating disc method was used to study the dissolution kinetics of ketanserin tartrate, the salt of a weakly basic drug. Both solubility and dissolution rate decrease exponentially with increasing pH of the dissolution medium. A plot of the logarithm of the ratio of dissolution rate to solubility vs the bulk solution pH shows increasing ratios with increasing pH. This phenomenon is attributed to a self-buffering action of the drug within the diffusion layer at the solid-solvent interface.
| Original language | English |
|---|---|
| Pages (from-to) | 161-165 |
| Number of pages | 5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 87 |
| Issue number | 1-3 |
| Publication status | Published - 10-Nov-1992 |
Keywords
- DISSOLUTION KINETICS
- WEAK BASE
- KETANSERIN TARTRATE
- DIFFUSION LAYER PH
- CARBOXYLIC-ACIDS
- SOLUBILITY
- HYDROCHLORIDE