Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment

Missak Haigentz, Dana M. Hartl, Carl E. Silver, Johannes A. Langendijk, Primoz Strojan, Vinidh Paleri, Remco de Bree, Jean-Pascal Machiels, Marc Hamoir, Alessandra Rinaldo, Daniela Paccagnella, Ashok R. Shaha, Robert P. Takes, Alfio Ferlito*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

Distant metastases from head and neck squamous cell carcinoma (HNSCC), though rare at initial presentation, remain an important manifestation of cancer recurrence and mortality. Although generally considered incurable with a dismal prognosis despite palliative therapy, highly selected patients with distant metastases may have a long term survival benefit from aggressive surgery or radiotherapy. Advances in systemic treatments also may improve patient survival. This article reviews the current state of management of HNSCC patients with distant metastases. (C) 2012 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)787-793
Number of pages7
JournalOral Oncology
Volume48
Issue number9
DOIs
Publication statusPublished - Sep-2012

Keywords

  • Distant metastases
  • Head and neck squamous cell carcinoma
  • Treatment
  • Chemotherapy
  • Metastasectomy
  • PLATINUM-BASED CHEMOTHERAPY
  • COOPERATIVE-ONCOLOGY-GROUP
  • CISPLATIN PLUS FLUOROURACIL
  • PULMONARY METASTASES
  • PHASE-II
  • RADIOFREQUENCY ABLATION
  • SURGICAL RESECTION
  • LARYNGEAL-CANCER
  • RANDOMIZED-TRIAL
  • SOLID TUMORS

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