Diversity of microRNAs in human and chimpanzee brain

Eugene Berezikov, Fritz Thuemmler, Linda W. Van Laake, Ivanela Kondova, Ronald Bontrop, Edwin Cuppen, R. H A Plasterk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

406 Citations (Scopus)


We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

Original languageEnglish
Pages (from-to)1375-1377
Number of pages3
JournalNature Genetics
Issue number12
Publication statusPublished - 5-Dec-2006

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