Abstract
The copper-catalyzed hetero-allylic asymmetric alkylation (h-AAA) of functionalized Grignard reagents that contain alkene or alkyne moieties has been achieved with excellent regio-and enantioselectivity. The corresponding alkylation products were further transformed into a variety of highly functionalized cyclic and bicyclic alcohols with excellent control over the chemo-, regio-, and stereoselectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 760-769 |
| Number of pages | 10 |
| Journal | Chemistry |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan-2013 |
Keywords
- alcohols
- asymmetric synthesis
- copper
- cyclization
- cycloaddition
- RING-CLOSING METATHESIS
- ASYMMETRIC ALLYLIC ALKYLATION
- PAUSON-KHAND REACTION
- DIELS-ALDER REACTIONS
- NATURAL-PRODUCT SYNTHESIS
- ONE-POT SYNTHESIS
- ENYNE METATHESIS
- OLEFIN METATHESIS
- CYCLOADDITION REACTIONS
- GRIGNARD-REAGENTS
Fingerprint
Dive into the research topics of 'Diversity-Oriented Enantioselective Synthesis of Highly Functionalized Cyclic and Bicyclic Alcohols'. Together they form a unique fingerprint.Datasets
-
CCDC 889474: Experimental Crystal Structure Determination
Mao, B. (Contributor), Fananas Mastral, M. (Contributor), Lutz, M. (Contributor) & Feringa, B. L. (Contributor), University of Groningen, 28-Jun-2012
DOI: 10.5517/ccyvkq1
Dataset