Dizygotic twin pregnancy after transfer of one embryo

Marie-Louise van der Hoorn*, Frans Helmerhorst, Frans Claas, Sicco Scherjon

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

18 Citations (Scopus)


Objective: To consider the risk of intercourse without contraception during infertility treatment.

Design: Case report.

Setting: Leiden University Medical Center.

Patient(s): An infertile couple underwent IVF for tubal pathology.

Intervention(s): Transfer of one embryo during a natural cycle.

Main Outcome Measure(s): Human leukocyte antigen typing, histochemical analysis of the fetal membranes, neonatal and maternal clinical outcomes.

Result(s): A dizygotic twin pregnancy was confirmed after birth by human leukocyte antigen typing of both fetuses and mother and by histochemical analysis of the dividing fetal membranes. This suggests a pregnancy of concurrent IVF and spontaneous conception. Pregnancy was complicated by preeclampsia and intrauterine growth retardation of both fetuses.

Conclusion(s): We state that couples should abstain from intercourse without contraception during infertility treatment to prevent multiple gestation and its related complications for mother and fetuses. (Fertil Steril (R) 2011;95:805.e1-e3. (C)2011 by American Society for Reproductive Medicine.)

Original languageEnglish
Article number805.e1
Number of pages3
JournalFertility and sterility
Issue number2
Publication statusPublished - Feb-2011
Externally publishedYes


  • IVF
  • twin pregnancy
  • dizygosity
  • intercourse without contraception

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