DNA and RNA induced enantioselectivity in chemical synthesis

Gerard Roelfes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)
24 Downloads (Pure)

Abstract

One of the hallmarks of DNA and RNA structures is their elegant chirality. Using these chiral structures to induce enantioselectivity in chemical synthesis is as enticing as it is challenging. In recent years, three general approaches have been developed to achieve this, including chirality transfer by nucleotide templated synthesis, enantio selective catalysis by RNA/DNAzymes and DNA-based asymmetric catalysis. In this article the concepts behind these strategies as well as the important achievements in this field will be discussed.

Original languageEnglish
Pages (from-to)126-135
Number of pages10
JournalMolecular BioSystems
Volume3
Issue number2
DOIs
Publication statusPublished - Feb-2007

Keywords

  • BIOTIN-AVIDIN TECHNOLOGY
  • CARBON BOND FORMATION
  • DIELS-ALDER REACTION
  • WATER-ENHANCED ENANTIOSELECTIVITY
  • IN-VITRO COMPARTMENTALIZATION
  • TEMPLATED ORGANIC-SYNTHESIS
  • NUCLEIC-ACID ENZYMES
  • ARTIFICIAL METALLOENZYMES
  • ACTIVE-SITE
  • DIRECTED EVOLUTION

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