Abstract
Here, the first examples of DNA-based organometallic catalysis in water that give rise to high enantioselectivities are described. Copper complexes of strongly intercalating ligands were found to enable the asymmetric intramolecular cyclopropanation of alpha-diazo-beta-keto sulfones in water. Up to 84% ee was achieved, in the presence of salmon testes DNA as the only source of chirality, using dipyrido [3,2-a: 2',3'-c] phenazine (dppz) derivatives as ligands.
Original language | English |
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Pages (from-to) | 2013-2017 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 4 |
Issue number | 5 |
DOIs | |
Publication status | Published - 15-Mar-2013 |
Keywords
- TRANSITION-METAL CATALYSIS
- MONODENTATE P-LIGANDS
- IN-SITU GENERATION
- CYCLOPROPANATION REACTIONS
- INTRAMOLECULAR CYCLOPROPANATION
- COMPLEXES
- ENANTIOSELECTIVITY
- MEDIA
- HYDROCHLORIDE
- INTERCALATORS