Do traditional cardiovascular risk factors solely explain intima-media thickening in youth with type 1 diabetes?

Josine C. van der Heyden*, Erwin Birnie, Sarah A. Bovenberg, Manuel Castro Cabezas, Noelle van der Meulen, Dick Mul, Henk J. Veeze, Henk-Jan Aanstoot

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Aims: The aim of this study was to assess age-specific carotid intima-media thickness (cIMT) in children and adolescents with type 1 diabetes and to investigate associations between cIMT, age, classical cardiovascular disease (CVD) and other risk factors.

Methods: This study included a cross-sectional analysis of cIMT in 178 patients with type 1 diabetes and 208 healthy controls across age categories. In patients, the impact of gender, socio-economic status, ethnicity, current and historical body mass index, blood pressure, hemoglobin A(1c), high-density lipoprotein, and low-density lipoprotein cholesterol on cIMT was studied in a retrospective follow-up cohort study.

Results: Median cIMT was equally greater in patients versus controls across all age categories (P

Conclusions: Children and adolescents with type 1 diabetes showed greater cIMT than controls in all age categories. Increased cIMT did not seem to be consistently associated with classical adult CVD risk factors, adding to the current debate in pediatrics about the impact on classical CVD risk factors to the development of subclinical atherosclerosis in type 1 diabetes. Future studies are warranted to determine if cIMT could assist in predicting macrovascular complications of type 1 diabetes. (C) 2016 Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)1137-1143
Number of pages7
JournalJOURNAL OF DIABETES AND ITS COMPLICATIONS
Volume30
Issue number6
DOIs
Publication statusPublished - Aug-2016

Keywords

  • Childhood
  • Diabetes
  • Lipids/lipoproteins
  • Macrovascular diseas
  • Complications
  • MYOCARDIAL-INFARCTION
  • THICKNESS
  • ATHEROSCLEROSIS
  • COMPLICATIONS
  • CHILDREN
  • ADOLESCENTS
  • PROGRESSION
  • STATEMENT
  • MELLITUS
  • DISEASE

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