Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors

EA van der Wouden*, RH Henning, LE Deelman, AJM Roks, F Boomsma, D de Zeeuw

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Angiotensin-converting enzyme inhibitors (ACE-I) reduce proteinuria and protect the kidney in proteinuric renal disease. During ACE-I therapy, circulating levels of angiotensin (1-7) [Ang (1-7)] are increased. As cardiac and renal protective effects of Ang (1-7) have been reported, we questioned whether Ang (1-7) contributes to the antiproteinuric effects of ACE-I treatment.

Therefore, we evaluated whether Ang (1-7) infusion reduces proteinuria in a rat model of adriamycin-induced renal disease. In addition, the effect of a selective Ang (1-7) blocker, [D-Ala(7)]-Ang (1-7) (A779), was investigated in rats treated with the ACE-1, lisinopril (LIS).

Six weeks after induction of proteinuria, therapy was started in four different groups: control, Ang (1-7), LIS, and LIS+A779. After two weeks, the rats were sacrificed. Six weeks after injection of adriamycin, the rats had developed proteinuria of 323 +/- 40 mg/24 hours. The proteinuria remained stable in the control group and in the Ang (1-7) group, but was reduced in both LIS and LIS+A779-treated groups. Similarly, blood pressure (BP) was unchanged in the control and the Ang (1-7) groups, but reduced in both the LIS and the LIS+A779 groups. Plasma levels of Ang (1-7) were increased in the Ang (1-7) and in both LIS-treated groups.

We conclude that systemic Ang (1-7) plays no major role in the antiproteinuric and BP-lowering effects of ACE-I in this rat model of adriamycin-induced nephrosis.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalJournal of the Renin-Angiotensin-Aldosterone System
Volume6
Issue number2
DOIs
Publication statusPublished - Sept-2005

Keywords

  • angiotensin (1-7)
  • ACE-inhibitors
  • proteinuria
  • BP
  • ESTABLISHED ADRIAMYCIN NEPHROSIS
  • CONVERTING-ENZYME-INHIBITORS
  • HEART-FAILURE
  • NATRIURETIC ACTION
  • HYPERTENSIVE-RATS
  • SYSTEM
  • ANTAGONIST
  • BRADYKININ
  • CARBOXYPEPTIDASE
  • PROTEINURIA

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