Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Renee Bouwstra*, Tom van Meerten, Edwin Bremer

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

3 Citations (Scopus)

Abstract

Innate immune checkpoint CD47 has emerged as a prominent target for cancer immunotherapy and defining biomarkers predictive of response will be a crucial step towards clinical implementation. Hereto, we investigated the importance of a previously reported requisite for SLAM family member 7(SLAMF7) expression on cancer cell phagocytosis for effective CD47 antibody therapy.

Original languageEnglish
Article number1600349
Number of pages3
JournalMolecular and Cellular Oncology
Volume6
Issue number3
DOIs
Publication statusPublished - 1-Jan-2019

Keywords

  • CD47
  • DLBCL
  • phagocytosis
  • SLAMF7

Cite this