Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Renee Bouwstra*, Tom van Meerten, Edwin Bremer

*Corresponding author for this work

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

    4 Citations (Scopus)
    38 Downloads (Pure)

    Abstract

    Innate immune checkpoint CD47 has emerged as a prominent target for cancer immunotherapy and defining biomarkers predictive of response will be a crucial step towards clinical implementation. Hereto, we investigated the importance of a previously reported requisite for SLAM family member 7(SLAMF7) expression on cancer cell phagocytosis for effective CD47 antibody therapy.

    Original languageEnglish
    Article number1600349
    Number of pages3
    JournalMolecular and Cellular Oncology
    Volume6
    Issue number3
    DOIs
    Publication statusPublished - 1-Jan-2019

    Keywords

    • CD47
    • DLBCL
    • phagocytosis
    • SLAMF7

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