Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study

T. Lataster, M. Wichers, N. Jacobs, R. Mengelers, C. Derom, E. Thiery, J. Van Os, I. Myin-Germeys*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

Objective: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. Method: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. Results: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. Conclusion: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume119
Issue number1
DOIs
Publication statusPublished - Jan-2009
Externally publishedYes

Keywords

  • stress reactivity
  • risk factors
  • psychosis
  • twin
  • experience sampling
  • DAILY-LIFE STRESS
  • SCHIZOTYPAL PERSONALITY-DISORDER
  • EMOTIONAL REACTIVITY
  • SCHIZOPHRENIC-PATIENTS
  • DELUSIONAL IDEATION
  • POSITIVE SYMPTOMS
  • NEGATIVE AFFECT
  • GENETIC RISK
  • CANNABIS USE
  • EXPERIENCES

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