Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity

G Imre; DS Fokkema; JA Den Boer; GJ Ter Horst

doi:10.1016/j.brainresbull.2006.01.010

Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity

G Imre^*, DS Fokkema, JA Den Boer, GJ Ter Horst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

112 Citations (Scopus)

Abstract

The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PP1), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined whether ketamine-induced locomotion was influenced by the dark/light cycle. We found that ketamine increased locomotor activity in a dose dependent manner, but found no influence of the dark-light cycle. Additionally, ketamine dose-dependently interrupted PP1, resulting in prepulse facilitation at doses of 8 and 12 mg/kg. The dose of 12 mg/kg also induced impairments in working memory assessed by the discrete-trial delayed-alternation task. C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala. (c) 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	338-345
Number of pages	8
Journal	Brain Research Bulletin
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/j.brainresbull.2006.01.010
Publication status	Published - 14-Apr-2006

Keywords

ketamine
light/dark cycle
hyperlocomotion
c-fos
PPI
working memory
schizophrenia
limbic system
NONCOMPETITIVE NMDA ANTAGONIST
METHYL-D-ASPARTATE
C-FOS EXPRESSION
IMMEDIATE-EARLY GENES
PREPULSE INHIBITION
PREFRONTAL CORTEX
RECEPTOR ANTAGONISTS
RAT-BRAIN
RETROSPLENIAL CORTICES
POSTERIOR CINGULATE

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title = "Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity",

abstract = "The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PP1), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined whether ketamine-induced locomotion was influenced by the dark/light cycle. We found that ketamine increased locomotor activity in a dose dependent manner, but found no influence of the dark-light cycle. Additionally, ketamine dose-dependently interrupted PP1, resulting in prepulse facilitation at doses of 8 and 12 mg/kg. The dose of 12 mg/kg also induced impairments in working memory assessed by the discrete-trial delayed-alternation task. C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala. (c) 2006 Elsevier Inc. All rights reserved.",

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author = "G Imre and DS Fokkema and {Den Boer}, JA and {Ter Horst}, GJ",

year = "2006",

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AU - Imre, G

AU - Fokkema, DS

AU - Den Boer, JA

AU - Ter Horst, GJ

PY - 2006/4/14

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N2 - The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PP1), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined whether ketamine-induced locomotion was influenced by the dark/light cycle. We found that ketamine increased locomotor activity in a dose dependent manner, but found no influence of the dark-light cycle. Additionally, ketamine dose-dependently interrupted PP1, resulting in prepulse facilitation at doses of 8 and 12 mg/kg. The dose of 12 mg/kg also induced impairments in working memory assessed by the discrete-trial delayed-alternation task. C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala. (c) 2006 Elsevier Inc. All rights reserved.

AB - The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PP1), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined whether ketamine-induced locomotion was influenced by the dark/light cycle. We found that ketamine increased locomotor activity in a dose dependent manner, but found no influence of the dark-light cycle. Additionally, ketamine dose-dependently interrupted PP1, resulting in prepulse facilitation at doses of 8 and 12 mg/kg. The dose of 12 mg/kg also induced impairments in working memory assessed by the discrete-trial delayed-alternation task. C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala. (c) 2006 Elsevier Inc. All rights reserved.

KW - ketamine

KW - light/dark cycle

KW - hyperlocomotion

KW - c-fos

KW - PPI

KW - working memory

KW - schizophrenia

KW - limbic system

KW - NONCOMPETITIVE NMDA ANTAGONIST

KW - METHYL-D-ASPARTATE

KW - C-FOS EXPRESSION

KW - IMMEDIATE-EARLY GENES

KW - PREPULSE INHIBITION

KW - PREFRONTAL CORTEX

KW - RECEPTOR ANTAGONISTS

KW - RAT-BRAIN

KW - RETROSPLENIAL CORTICES

KW - POSTERIOR CINGULATE

U2 - 10.1016/j.brainresbull.2006.01.010

DO - 10.1016/j.brainresbull.2006.01.010

M3 - Article

SN - 0361-9230

VL - 69

SP - 338

EP - 345

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 3

ER -

Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity

Abstract

Keywords

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