Dose-response Relation, Neuromuscular Blocking Action, Intubation Conditions, and Cardiovascular Effects of Org 9273, a New Neuromuscular Blocking Agent

L van den Broek, L.M Lambalk, F.J Richardson, J.M.K.H Wierda

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    Abstract

    The ED50 and the ED90, the time-course of the neuromuscular block, the intubation conditions, and the cardiovascular effects of Org 9273, a new steroidal nondepolarizing neuromuscular blocking agent, have been evaluated in 41 anesthetized patients. From cumulative dose-response curves the ED50 and ED90 were calculated to be 175 and 300-mu-g/kg, respectively. The time-course of neuromuscular blockade after 300- and 500-mu-g/kg doses of Org 9273 appeared to be similar to that of equipotent doses of vecuronium. The neuromuscular block was characterized by a fast initial rate of block development. High-dose Org 9273 (1 mg/kg = 3-4 times the ED90) had a clinical duration comparable to an intubating dose of pancuronium, but a considerably more rapid onset and recovery index. Three hundred micrograms per kilogram and 500-mu-g/kg Org 9273 produced good to excellent intubation conditions 1 min after administration. Org 9273 in a dose of 0.5-2 times the ED90 produced no cardiovascular changes; however, 3-4 times the ED90 increased heart rate 20%-25% (P <0.001), probably due to vagolytic effect.

    Original languageEnglish
    Pages (from-to)811-816
    Number of pages6
    JournalAnesthesia and Analgesia
    Volume72
    Issue number6
    Publication statusPublished - Jun-1991

    Keywords

    • NEUROMUSCULAR RELAXANT, ORG-9273
    • PANCURONIUM
    • VECURONIUM
    • ORG-NC45

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