Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 Diabetics

Willem Nesse*, Annemiek Linde, Frank Abbas, Frederik Karst Lucien Spijkervet, Pieter Ubele Dijkstra, Eric Carl de Brabander, Izzy Gerstenbluth, Arjan Vissink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)
556 Downloads (Pure)

Abstract

Nesse W, Linde A, Abbas F, Spijkervet FKL, Dijkstra PU, de Brabander EC, Gerstenbluth I, Vissink A. Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 diabetics. J Clin Periodontol 2009; 36: 295-300. doi: 10.1111/j.1600-051X.2009.01377.x.

A dose-response relationship between the amount of inflamed periodontal tissue and HbA1c level, might be indicative for a causal association between periodontitis and type 2 diabetes.

To assess a dose-response relationship between the periodontal inflamed surface area (PISA), as a measure of the amount of inflamed periodontal tissue, and HbA1c levels in type 2 diabetics.

Forty consecutive dentate type 2 diabetics attending their general practitioner for regular check-up, underwent full-mouth probing pocket depth and bleeding on probing assessment. From these data PISA was calculated. HbA1c levels were retrieved from patients' medical files. The dose-response relationship between PISA and HbA1c levels was assessed using multiple linear regression analyses, controlling for factors that might influence PISA or HbA1c levels.

The higher the PISA of type 2 diabetics was, the higher their HbA1c levels were. On a group level, an increase of PISA with 333 mm(2) was associated with a 1.0 percentage point increase of HbA1c, independent of the influence of other factors.

On a group level, there is a dose-response relationship between PISA and HbA1c in type 2 diabetics. This might be an indication of a causal relationship between type 2 diabetes and periodontitis.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalJournal of Clinical Periodontology
Volume36
Issue number4
DOIs
Publication statusPublished - Apr-2009

Keywords

  • glycosylated hemoglobin A
  • periodontal inflamed surface area (PISA)
  • periodontitis
  • type 2 diabetes mellitus
  • TUMOR-NECROSIS-FACTOR
  • GLYCEMIC CONTROL
  • INFLAMMATORY MARKERS
  • GLYCATED HEMOGLOBIN
  • FACTOR-ALPHA
  • MELLITUS
  • DISEASE
  • RISK
  • THERAPY
  • HEALTH

Cite this