Drastic improvement in the rectal absorption profile of morphine in man

F  Moolenaar; JP Yska; J Visser; DKF Meijer

doi:10.1007/BF00547380

Drastic improvement in the rectal absorption profile of morphine in man

F Moolenaar^*
, JP Yska
, J Visser
, DKF Meijer

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

32 Citations (Scopus)

Abstract

Rectal absorption of morphine HCl from aqueous vehicles at different pHs in man has been compared with an orally administered solution. Plasma concentrations of morphine were measured by electrochemical HPLC analysis after a single dose of 10 mg morphine HCl, in a cross-over study in 7 volunteers. Rectal absorption of morphine was dependent on pH, which could be explained as being due to pH partitioning. The absorption rate and bioavailability could be greatly improved, as compared to orally administered morphine, by adjusting the pH. It was concluded that a rectal solution adjusted to pH 7 to 8 provided an entirely adequate dosage form.

Original language	English
Pages (from-to)	119-121
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1007/BF00547380
Publication status	Published - 1985

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title = "Drastic improvement in the rectal absorption profile of morphine in man",

abstract = "Rectal absorption of morphine HCl from aqueous vehicles at different pHs in man has been compared with an orally administered solution. Plasma concentrations of morphine were measured by electrochemical HPLC analysis after a single dose of 10 mg morphine HCl, in a cross-over study in 7 volunteers. Rectal absorption of morphine was dependent on pH, which could be explained as being due to pH partitioning. The absorption rate and bioavailability could be greatly improved, as compared to orally administered morphine, by adjusting the pH. It was concluded that a rectal solution adjusted to pH 7 to 8 provided an entirely adequate dosage form.",

author = "F Moolenaar and JP Yska and J Visser and DKF Meijer",

year = "1985",

doi = "10.1007/BF00547380",

language = "English",

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journal = "European Journal of Clinical Pharmacology",

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T1 - Drastic improvement in the rectal absorption profile of morphine in man

AU - Moolenaar, F

AU - Yska, JP

AU - Visser, J

AU - Meijer, DKF

PY - 1985

Y1 - 1985

N2 - Rectal absorption of morphine HCl from aqueous vehicles at different pHs in man has been compared with an orally administered solution. Plasma concentrations of morphine were measured by electrochemical HPLC analysis after a single dose of 10 mg morphine HCl, in a cross-over study in 7 volunteers. Rectal absorption of morphine was dependent on pH, which could be explained as being due to pH partitioning. The absorption rate and bioavailability could be greatly improved, as compared to orally administered morphine, by adjusting the pH. It was concluded that a rectal solution adjusted to pH 7 to 8 provided an entirely adequate dosage form.

AB - Rectal absorption of morphine HCl from aqueous vehicles at different pHs in man has been compared with an orally administered solution. Plasma concentrations of morphine were measured by electrochemical HPLC analysis after a single dose of 10 mg morphine HCl, in a cross-over study in 7 volunteers. Rectal absorption of morphine was dependent on pH, which could be explained as being due to pH partitioning. The absorption rate and bioavailability could be greatly improved, as compared to orally administered morphine, by adjusting the pH. It was concluded that a rectal solution adjusted to pH 7 to 8 provided an entirely adequate dosage form.

U2 - 10.1007/BF00547380

DO - 10.1007/BF00547380

M3 - Comment/Letter to the editor

SN - 0031-6970

VL - 29

SP - 119

EP - 121

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 1

ER -

Drastic improvement in the rectal absorption profile of morphine in man

Abstract

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