Drug-induced hyperthermia in Huntington's disease

D Gaasbeek, Paul Naarding, T Stor, H P H Kremer

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4 Citations (Scopus)


Until now, only three patients with Huntington's disease (HD) and a neuroleptic malignant syndrome (NMS) have been reported in the literature. We describe four cases with advanced stage Huntington's disease who within a period of one year developed drug-induced hyperthermia, either the neuroleptic malignant syndrome, or the serotonin syndrome. Possible contributing factors that may have been specific for HD patients could be identified and included advanced neurological disease with severe illness, occurrence in summer, with possible infectious disease, dehydration, and pre-existing extra-pyramidal signs that may mask incipient NMS/serotonin syndrome. Measures to avoid these potentially lifethreatening conditions are discussed.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalJournal of Neurology
Issue number4
Publication statusPublished - Apr-2004


  • Adult
  • Female
  • Fever
  • Humans
  • Huntington Disease
  • Male
  • Middle Aged
  • Neuroleptic Malignant Syndrome
  • Serotonin Syndrome
  • Case Reports
  • Journal Article

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