DRUG-RESISTANCE, SUPPORTIVE CARE AND DOSE INTENSITY

EGE DEVRIES*, TC HAMILTON, M LIND, J DAUPLAT, JP NEIJT, RF OZOLS

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Background: Both intrinsic and acquired drug resistance occur in ovarian cancer. Much work on in vivo or in vitro, obtained drug resistance has been done and this knowledge is presently being converted into clinical studies. Materials and methods: The review focuses on the detoxifying system, MDR (multidrug resistance), and supportive care in relation to dose intensity. Results: In vitro models suggest that the amount of glutathione, glutathione S-transferase activity or metallothioneins could play a role in the outcome of chemotherapy treatment. The results of human tumour samples studies however do not support this idea. Expression of the cell membrane P-glycoprotein in tumour cells appears in vitro to be an important adverse prognostic factor concerning the effect of natural products. Again the results in human tumour samples vary. The supportive agent sodium thiosulphate protects against cisplatin induced nephrotoxicity, but the exact role of sulphur compounds in ameliorating the neurotoxicity is not yet established. The neuropeptide Org 2766 may be a possible neuro- protector. Hemopoietic growth factors such as GM-CSF, G-CSF and interleukin-3, protect the bone marrow to varying degrees. Autologous bone marrow transplantation induces high, but often short lasting response rates in chemotherapy resistant patients. Conclusions: More clinical studies on intervention of drug resistance and on high dose chemotherapy are needed to define the role of these strategies in ovarian cancer.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalAnnals of Oncology
Volume4
Publication statusPublished - 1993
EventInternational Workshop on Advanced Ovarian Cancer: where Do We Stand and Where Do We Go - , Denmark
Duration: 15-Jun-199319-Jun-1993

Keywords

  • DRUG RESISTANCE
  • SUPPORTIVE CARE
  • OVARIAN CANCER
  • COLONY-STIMULATING FACTOR
  • BONE-MARROW TRANSPLANTATION
  • PLATINUM CYCLOPHOSPHAMIDE CHEMOTHERAPY
  • REFRACTORY OVARIAN-CANCER
  • S-TRANSFERASE ACTIVITY
  • PHASE-I
  • SOLID TUMORS
  • CARBOPLATIN
  • CISPLATIN
  • CARCINOMA

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