Dual time-point imaging for post-dose binding potential estimation applied to a [C-11]raclopride PET dose occupancy study

Isadora Lopes Alves, Antonius Willemsen, Rudi A. Dierckx, Ana Maria Marques da Silva, Michel J. B. Koole

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Receptor occupancy studies performed with PET often require time-consuming dynamic imaging for baseline and post-dose scans. Shorter protocol approximations based on standard uptake value ratios have been proposed. However, such methods depend on the time-point chosen for the quantification and often lead to overestimation and bias. The aim of this study was to develop a shorter protocol for the quantification of post-dose scans using a dual time-point approximation, which employs kinetic parameters from the baseline scan. Dual time-point was evaluated for a [C-11]raclopride PET dose occupancy study with the D2 antagonist JNJ-37822681, obtaining estimates for binding potential and receptor occupancy. Results were compared to standard simplified reference tissue model and standard uptake value ratios-based estimates. Linear regression and Bland-Altman analysis demonstrated excellent correlation and agreement between dual time-point and the standard simplified reference tissue model approach. Moreover, the stability of dual time-point-based estimates is shown to be independent of the time-point chosen for quantification. Therefore, a dual time-point imaging protocol can be applied to post-dose [C-11]raclopride PET scans, resulting in a significant reduction in total acquisition time while maintaining accuracy in the quantification of both the binding potential and the receptor occupancy.

Original languageEnglish
Pages (from-to)866-876
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number3
Early online date16-Apr-2016
DOIs
Publication statusPublished - 1-Mar-2017

Keywords

  • Dual time-point
  • positron emission tomography
  • quantification
  • binding potential
  • [C-11]raclopride
  • POSITRON-EMISSION-TOMOGRAPHY
  • REFERENCE TISSUE MODEL
  • RECEPTOR OCCUPANCY
  • GRAPHICAL ANALYSIS
  • RACLOPRIDE
  • JNJ-37822681
  • BRAIN

Cite this