Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Research output: Contribution to journalArticleAcademicpeer-review

91 Downloads (Pure)

Abstract

Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60-75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

Original languageEnglish
Article number580
Number of pages10
JournalNutrients
Volume12
Issue number2
DOIs
Publication statusPublished - 23-Feb-2020

Keywords

  • elderly
  • vitamin E
  • tocopherol
  • total lipids
  • insulin resistance syndrome
  • one-carbon metabolism
  • pyridoxal phosphate
  • cobalamin
  • folate
  • homocysteine
  • TANDEM MASS-SPECTROMETRY
  • DIETARY ALPHA-TOCOPHEROL
  • BONE-MINERAL DENSITY
  • OXIDATIVE STRESS
  • GAMMA-TOCOPHEROL
  • ENDOTHELIAL DYSFUNCTION
  • INSULIN-RESISTANCE
  • SERUM
  • PLASMA
  • LIVER

Cite this