Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers

Roos S G Sablerolles, Wim J R Rietdijk, Abraham Goorhuis, Douwe F Postma, Leo G Visser, Katharina S Schmitz, Daryl Geers, Susanne Bogers, Eva van Haren, Marion P G Koopmans, Virgil A S H Dalm, Neeltje A Kootstra, Anke L W Huckriede, Renate Akkerman, Martin Beukema, Melvin Lafeber, Debbie van Baarle, Rory D de Vries, P Hugo M van der Kuy, Corine H Geurts van Kessel

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The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous booster vaccination after Ad26.COV2.S priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

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