Dutch Resolution: Dutch Resolution, a New Technology in Classical Resolution

Quirinus B. Broxterman; Erik van Echten; Lumbertus A. Hulshof; Bernard Kaptein; Richard M. Kellogg; Adriaan J. Minnaard; Ton R. Vries; Hans Wynberg

doi:10.1002/chin.199907313

Dutch Resolution: Dutch Resolution, a New Technology in Classical Resolution

Quirinus B. Broxterman, Erik van Echten, Lumbertus A. Hulshof, Bernard Kaptein, Richard M. Kellogg, Adriaan J. Minnaard, Ton R. Vries, Hans Wynberg

Synthetic Organic Chemistry

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Abstract

A new method for the resolution of racemates through diastereomeric salt formation is presented. An essential feature of this new method is the use of mixtures of resolving agents. The application of certain mixtures results in an efficient and fast crystallisation of enantiomerically enriched salts. It turns out that these salts still contain a mixture of the resolving agents. Via this new method, referred to as the Dutch Resolution (DR) technology, the success rate in identifying and performing adequate resolutions of racemates has been greatly improved.

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	Chimica Oggi-Chemistry Today
Volume	30
Issue number	7
DOIs	https://doi.org/10.1002/chin.199907313
Publication status	Published - 16-Feb-1999

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Dutch Resolution, a New Technology in Classical ResolutionFinal publisher's version, 142 KBLicence: Taverne

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title = "Dutch Resolution: Dutch Resolution, a New Technology in Classical Resolution",

abstract = "A new method for the resolution of racemates through diastereomeric salt formation is presented. An essential feature of this new method is the use of mixtures of resolving agents. The application of certain mixtures results in an efficient and fast crystallisation of enantiomerically enriched salts. It turns out that these salts still contain a mixture of the resolving agents. Via this new method, referred to as the Dutch Resolution (DR) technology, the success rate in identifying and performing adequate resolutions of racemates has been greatly improved.",

author = "Broxterman, {Quirinus B.} and Echten, {Erik van} and Hulshof, {Lumbertus A.} and Bernard Kaptein and Kellogg, {Richard M.} and Minnaard, {Adriaan J.} and Vries, {Ton R.} and Hans Wynberg",

note = "Relation: http://www.rug.nl/scheikunde/ date_submitted:2005 Rights: University of Groningen. Stratingh Institute",

year = "1999",

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doi = "10.1002/chin.199907313",

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T2 - Dutch Resolution, a New Technology in Classical Resolution

AU - Broxterman, Quirinus B.

AU - Echten, Erik van

AU - Hulshof, Lumbertus A.

AU - Kaptein, Bernard

AU - Kellogg, Richard M.

AU - Minnaard, Adriaan J.

AU - Vries, Ton R.

AU - Wynberg, Hans

N1 - Relation: http://www.rug.nl/scheikunde/ date_submitted:2005 Rights: University of Groningen. Stratingh Institute

PY - 1999/2/16

Y1 - 1999/2/16

N2 - A new method for the resolution of racemates through diastereomeric salt formation is presented. An essential feature of this new method is the use of mixtures of resolving agents. The application of certain mixtures results in an efficient and fast crystallisation of enantiomerically enriched salts. It turns out that these salts still contain a mixture of the resolving agents. Via this new method, referred to as the Dutch Resolution (DR) technology, the success rate in identifying and performing adequate resolutions of racemates has been greatly improved.

AB - A new method for the resolution of racemates through diastereomeric salt formation is presented. An essential feature of this new method is the use of mixtures of resolving agents. The application of certain mixtures results in an efficient and fast crystallisation of enantiomerically enriched salts. It turns out that these salts still contain a mixture of the resolving agents. Via this new method, referred to as the Dutch Resolution (DR) technology, the success rate in identifying and performing adequate resolutions of racemates has been greatly improved.

U2 - 10.1002/chin.199907313

DO - 10.1002/chin.199907313

M3 - Article

SN - 0392-839X

VL - 30

SP - 34

EP - 37

JO - Chimica Oggi-Chemistry Today

JF - Chimica Oggi-Chemistry Today

IS - 7

ER -

Dutch Resolution: Dutch Resolution, a New Technology in Classical Resolution

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