TY - JOUR
T1 - Dynamic combinatorial chemistry
AU - Otto, Sijbren
AU - Furlan, Ricardo L. E.
AU - Sanders, Jeremy K. M.
N1 - Relation: http://www.rug.nl/scheikunde/onderzoek/scholen/stratingh/index
date_submitted:2009
Rights: University of Groningen, Stratingh Institute for Chemistry
PY - 2002/1/15
Y1 - 2002/1/15
N2 - A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional combinatorial chemistry, and that could make a useful addition to the set of combinatorial techniques used in drug discovery.
AB - A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional combinatorial chemistry, and that could make a useful addition to the set of combinatorial techniques used in drug discovery.
U2 - 10.1016/S1359-6446(02)00006-5
DO - 10.1016/S1359-6446(02)00006-5
M3 - Article
SN - 1359-6446
VL - 7
SP - 117
EP - 125
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 3
ER -