Dynamic Combinatorial Libraries of Disulfide Cages in Water

Kevin R. West; Kyle D. Bake; Sijbren Otto

doi:10.1021/ol0507524

Dynamic Combinatorial Libraries of Disulfide Cages in Water

Kevin R. West, Kyle D. Bake, Sijbren Otto

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Abstract

Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.

Original language	English
Number of pages	4
Journal	Organic letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1021/ol0507524
Publication status	Published - 2005

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title = "Dynamic Combinatorial Libraries of Disulfide Cages in Water",

abstract = "Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.",

author = "West, {Kevin R.} and Bake, {Kyle D.} and Sijbren Otto",

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AU - Bake, Kyle D.

AU - Otto, Sijbren

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PY - 2005

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N2 - Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.

AB - Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.

U2 - 10.1021/ol0507524

DO - 10.1021/ol0507524

M3 - Article

SN - 1523-7052

VL - 7

JO - Organic letters

JF - Organic letters

IS - 13

ER -

Dynamic Combinatorial Libraries of Disulfide Cages in Water

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