Dynamic models for health economic assessments of pertussis vaccines: what goes around comes around ...

M.H. Rozenbaum, E. De Cao, T.A. Westra, M.J. Postma

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Despite childhood vaccination programs, pertussis remains endemic. To reduce the burden of pertussis, various extended pertussis vaccination strategies have been suggested. The aim of this article is to evaluate dynamic models used to assess the cost-effectiveness of vaccination. In total, 16 studies using a dynamic model were included, of which four also studied the cost-effectiveness of extended pertussis vaccination strategies. Generally, adolescent vaccination was found to be cost effective, but not highly effective in protecting infants too young to be vaccinated. The models also predicted that owing to age shifts, reduced pertussis disease in adolescents and young adults comes with an increase in later stages of life. This underpins the use of dynamic transmission models for interventions directed against pertussis. In future, dynamic transmission models for pertussis should be used widely to further enhance understanding of pertussis epidemiology and of extended pertussis vaccination programs that are currently considered in various countries
Original languageEnglish
Pages (from-to)1415-1428
Number of pages14
JournalExpert review of vaccines
Volume11
Issue number12
DOIs
Publication statusPublished - Dec-2012

Keywords

  • booster vaccination
  • cost effective
  • dynamic modeling
  • epidemiology
  • models
  • pertussis
  • transmission
  • vaccination
  • whooping cough
  • PNEUMOCOCCAL CONJUGATE VACCINE
  • COST-EFFECTIVENESS
  • UNITED-STATES
  • BORDETELLA-PERTUSSIS
  • BOOSTER VACCINATION
  • HERPES-ZOSTER
  • HERD-IMMUNITY
  • WHOOPING-COUGH
  • DISEASE BURDEN
  • NASOPHARYNGEAL COLONIZATION

Cite this