Dynamics of inner ear pressure release, measured with a double-barreled micropipette in the guinea pig

HP Wit*, EO Thalen, FWJ Albers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

The inner ear, fluid pressure was measured in scala media of the guinea pig through one barrel of a double-barreled micropipette after a sudden volume increase or decrease, caused by injection or withdrawal of artificial endolymph through the other barrel. During injection or withdrawal, the inner ear pressure changed in the order of 1-10 cm water, but it returned to its initial value within a few seconds. The time constant for the pressure recovery depended on the flow direction. It was on average 1.1 s after a short overpressure and 2.8 s after underpressure. The obtained results could be fitted with a simple physical model, when it was assumed that inner ear pressure recovery is a non-linear process, governed by a pressure-dependent flow resistance and/or membrane compliance. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalHearing Research
Volume132
Issue number1-2
Publication statusPublished - Jun-1999

Keywords

  • cochlea
  • hydrops
  • endolymph
  • Meniere
  • aqueduct
  • HYDROSTATIC-PRESSURE
  • COCHLEAR AQUEDUCT
  • ENDOLYMPHATIC HYDROPS
  • ROUND WINDOW
  • PERILYMPH
  • MEMBRANE
  • PATENCY

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